Biography
In his research, Corvera focuses on the mechanisms that underlie inflammation, thickening and scarring in the biliary tract.
Corvera graduated from the University of California, San Diego School of Medicine. He completed a residency in general surgery at UCSF. At Memorial Sloan Kettering Cancer Center in New York City, he completed a clinical fellowship in surgical oncology as well as a fellowship in hepatobiliary surgery.
Videos
Education
| Institution | Degree | Dept or School | End Date | 
|---|---|---|---|
| Memorial Sloan Kettering Cancer Center, New York | Hepatobiliary Surgery | Surgery | 2002 | 
| Memorial Sloan Kettering Cancer Center , New York | Surgical Oncology Clinical Fellowship | Surgery | 2001 | 
| University of California, San Francisco | General Surgery Residency | School of Medicine | 2000 | 
| University of California San Diego | M.D. | School of Medicine | 1993 | 
Board Certifications
- American Board of Surgery
Clinical Expertise
Ascites
Bile Duct Injuries
Bile Duct Strictures
Bile Duct Cancer (Cholangiocarcinoma)
Gastrointestinal Carcinoid Tumor
Gastrointestinal Stromal Tumor (GIST)
Choledochal Cysts
Portal Hypertension
Liver Cancer (Hepatocellular Carcinoma)
Minimally Invasive Liver & Pancreas Surgery
Melanoma
Pancreatic Cancer
Pancreatic Cysts
Soft Tissue Sarcomas
Liver Cysts
Liver Metastases
Gallbladder Cancer
Stomach (Gastric) Cancer
Pancreatic Neuroendocrine (Islet Cell) Tumors
Bridging Therapies to Downstage HCC in Setting of Liver Transplantation
Program Affiliations
Hepatobiliary and Pancreas Surgery Program
UCSF Helen Diller Family Comprehensive Cancer Center
UCSF Department of Surgery at the San Francisco VA
Research Narrative
Dr. Corvera's scientific research interest is focused on understanding the mechanisms of biliary tract fibrosis and inflammation. More specifically, he is interested in studying the clinical consequences of biliary fibrosis-- mainly cholestatisis. Cholestasis is characterized by impaired bile flow causing a high concentration of bile acids in the liver and the circulation. Prolonged exposure to bile acids in the liver can progress to end-stage liver disease and cirrhosis. In the gastrointestinal tract, the absence of bile flow causes profound local and systemic metabolic disturbances. Dr.Corvera is actively investigating the role of a novel cell surface receptor specific for bile acids that may play a critical role in normal and disease states.
Research Interests
Proteases and Proteinase Activated Receptors in the Biliary Tract
Publications
- Minimally Invasive Versus Open Resection for Solid Pseudopapillary Tumors of the Pancreas: A Propensity Score-Matched Analysis.| | PubMed PubMed
- Gastric Cancer, Version 2.2025, NCCN Clinical Practice Guidelines In Oncology.| | PubMed PubMed
- Robotic-assisted trans-mesocolic side-to-side duodenojejunostomy for palliative management of malignant distal duodenal obstruction.| | PubMed PubMed
- Ongoing Failure to Deliver Guideline-Concordant Care for Patients with Pancreatic Cancer.| | PubMed PubMed
- ASO Author Reflections: Innovative Robot-Assisted Endoluminal Resection for Gastroesophageal Junction Leiomyomas.| | PubMed PubMed
- Robotic-Assisted Endoluminal Resection of Gastroesophageal Junction Leiomyoma with Transoral Specimen Extraction: Technique, Outcome, and Safety.| | PubMed PubMed
- Adult Pancreatoblastoma: Clinical Insights and Outcomes Compared to Pancreatic Ductal Adenocarcinoma (PDAC).| | PubMed PubMed
- Prognostic implications of margin status in association with systemic treatment in a cohort study of patients with resection of colorectal liver metastases.| | PubMed PubMed
- Graft choice in pancreatectomy with vascular resection: equivalent safety in selected patients.| | PubMed PubMed
- Resection versus resection with ablation: Analysis from the colorectal liver operative metastasis international collaborative.| | PubMed PubMed
- ASO Visual Abstract: Long-Duration Neoadjuvant Therapy with FOLFIRINOX Yields Favorable Outcomes for Patients Who Undergo Surgery for Pancreatic Cancer.| | PubMed PubMed
- Distinct Indications for Adjuvant Therapy in Resected Invasive Mucinous Cystic Neoplasms of the Pancreas Compared with Pancreatic Ductal Adenocarcinoma.| | PubMed PubMed
- Minimal Residual Disease using a Plasma-Only Circulating Tumor DNA Assay to Predict Recurrence of Metastatic Colorectal Cancer Following Curative Intent Treatment.| | PubMed PubMed
- Long-Duration Neoadjuvant Therapy with FOLFIRINOX Yields Favorable Outcomes for Patients Who Undergo Surgery for Pancreatic Cancer.| | PubMed PubMed
- Long-Term Survival Outcomes After Minimally Invasive Surgery for Ileal Neuroendocrine Tumors.| | PubMed PubMed
- National practice patterns in the use of endoscopic ultrasound biopsy for resectable Pancreatic Neuroendocrine Tumors: Insights into the role of DOTATATE PET/CT in diagnosis.| | PubMed PubMed
- Recurrence and tumor-related death after resection of hepatocellular carcinoma in patients with metabolic syndrome.| | PubMed PubMed
- Metastatic melanoma to small bowel: metastasectomy is supported in the era of immunotherapy and checkpoint inhibitors.| | PubMed PubMed
- Portal Vein Thrombosis After Transarterial Embolization for Hepatocellular Carcinoma.| | PubMed PubMed
- Intraoperative hepatic artery infusion pump perfusion testing with indocyanine green near-infrared imaging offers multiple potential advantages.| | PubMed PubMed
- Improved survival of patients receiving immunotherapy and chemotherapy following curative-intent resection of colorectal liver metastases.| | PubMed PubMed
- A Machine Learning Approach to Predict Postoperative Pancreatic Fistula After Pancreaticoduodenectomy Using Only Preoperatively Known Data.| | PubMed PubMed
- ASO Visual Abstract: National Practice Patterns in Malignant Peritoneal Mesothelioma-Updates in Management and Survival.| | PubMed PubMed
- National Practice Patterns in Malignant Peritoneal Mesothelioma: Updates in Management and Survival.| | PubMed PubMed
- Metastatic colorectal adenocarcinoma tumor purity assessment from whole exome sequencing data.| | PubMed PubMed
- Esophageal and Esophagogastric Junction Cancers, Version 2.2023, NCCN Clinical Practice Guidelines in Oncology.| | PubMed PubMed
- Minimally Invasive Versus Open Liver Resections for Hepatocellular Carcinoma in Patients With Metabolic Syndrome.| | PubMed PubMed
- Conditional Survival After Hepatectomy for Colorectal Liver Metastasis: Results from the Colorectal Liver Operative Metastasis International Collaborative (COLOMIC).| | PubMed PubMed
- Survival Outcomes of Optimally Treated Colorectal Metastases: The Importance of R0 Status in Surgical Treatment of Hepatic and Peritoneal Surface Disease.| | PubMed PubMed
- Machine Learning Models for Predicting the Outcomes of Surgical Treatment of Colorectal Liver Metastases.| | PubMed PubMed
- Hypertension Requiring Medication Use: a Silent Predictor of Poor Outcomes After Pancreaticoduodenectomy.| | PubMed PubMed
- Model to predict major complications following liver resection for HCC in patients with metabolic syndrome.| | PubMed PubMed
- Contemporary Trends in Malignant Peritoneal Mesothelioma: Incidence and Survival in the United States.| | PubMed PubMed
- Hand-Assisted Versus Pure Minimally-Invasive Distal Pancreatectomy: Is There a Downside to Lending a Hand?| | PubMed PubMed
- Minimally Invasive Distal Pancreatectomy Techniques: A Contemporary Analysis Exploring Trends, Similarities, and Differences to Open Surgery.| | PubMed PubMed
- Outcomes after repeat hepatectomy for colorectal liver metastases from the colorectal liver operative metastasis international collaborative (COLOMIC).| | PubMed PubMed
- Primary Cutaneous Malignant Perivascular Epithelioid Cell Tumor Mimicking Undifferentiated Pleomorphic Sarcoma: A Report of a Rare Entity.| | PubMed PubMed
- Perioperative chemotherapy for resectable colorectal liver metastases: Analysis from the Colorectal Operative Liver Metastases International Collaborative (COLOMIC).| | PubMed PubMed
- Association of primary tumor laterality with surgical outcomes for colorectal liver metastases: results from the Colorectal Liver Operative Metastasis International Collaborative (COLOMIC).| | PubMed PubMed
- Gastric Cancer, Version 2.2022, NCCN Clinical Practice Guidelines in Oncology.| | PubMed PubMed
- ASO Visual Abstract: Determining Hospital Volume Threshold for the Safety of Minimally Invasive Pancreaticoduodenectomy: A Contemporary Cutpoint Analysis.| | PubMed PubMed
- Determining Hospital Volume Threshold for Safety of Minimally Invasive Pancreaticoduodenectomy: A Contemporary Cutpoint Analysis.| | PubMed PubMed
- Multifocal pancreatic PPoma in the setting of MEN1: Case report and review of literature.| | PubMed PubMed
- Burden of Ionizing Radiation in the Diagnosis and Management of Necrotizing Pancreatitis.| | PubMed PubMed
- Minimally Invasive Surgery for Ileal Neuroendocrine Tumors.| | PubMed PubMed
- Contemporary Management of Hepatic Cyst Disease: Techniques and Outcomes at a Tertiary Hepatobiliary Center.| | PubMed PubMed
- Synchronous Versus Metachronous Colorectal Liver Metastasis Yields Similar Survival in Modern Era.| | PubMed PubMed
- A rare presentation of hepatolithiasis in an adolescent patient: A case report.| | PubMed PubMed
- Ampullary stenosis and choledocholithiasis post Roux-En-Y gastric bypass: challenges of biliary access and intervention.| | PubMed PubMed
- A novel stratification of mesenteric mass involvement as a predictor of challenging mesenteric lymph node dissection by minimally invasive approach for ileal neuroendocrine tumors.| | PubMed PubMed
- Residual tumor volume discriminates prognosis after surgery for neuroendocrine liver metastasis.| | PubMed PubMed
- Prognostic impact of a large mesenteric mass >2 cm in ileal neuroendocrine tumors.| | PubMed PubMed
- Esophageal and Esophagogastric Junction Cancers, Version 2.2019, NCCN Clinical Practice Guidelines in Oncology.| | PubMed PubMed
- Comparison of Tumor Regression Grading of Residual Pancreatic Ductal Adenocarcinoma Following Neoadjuvant Chemotherapy Without Radiation: Would Fewer Tier-Stratification Be Favorable Toward Standardization?| | PubMed PubMed
- Evaluation of an abbreviated screening MRI protocol for patients at risk for hepatocellular carcinoma.| | PubMed PubMed
- Change in Liver Imaging Reporting and Data System Characterization of Focal Liver Lesions Using Gadoxetate Disodium Magnetic Resonance Imaging Compared With Contrast-Enhanced Computed Tomography.| | PubMed PubMed
- Multiple arterial phase MRI of arterial hypervascular hepatic lesions: improved arterial phase capture and lesion enhancement.| | PubMed PubMed
- Imaging Hepatocellular Carcinoma With 68Ga-Citrate PET: First Clinical Experience.| | PubMed PubMed
- Preoperative FOLFIRINOX for borderline resectable pancreatic cancer: Is radiation necessary in the modern era of chemotherapy?| | PubMed PubMed
- In Vivo Hepatic Reprogramming of Myofibroblasts with AAV Vectors as a Therapeutic Strategy for Liver Fibrosis.| | PubMed PubMed
- Management of Postoperative Hepatic Failure.| | PubMed PubMed
- Correcting for respiratory motion in liver PET/MRI: preliminary evaluation of the utility of bellows and navigated hepatobiliary phase imaging.| | PubMed PubMed
- The bile acid receptor TGR5 activates the TRPA1 channel to induce itch in mice.| | PubMed PubMed
- Impact of pre-operative positron emission tomography in gallbladder cancer.| | PubMed PubMed
- Expanded use of aggressive therapies improves survival in early and intermediate hepatocellular carcinoma.| | PubMed PubMed
- The bile acid receptor TGR5 does not interact with β-arrestins or traffic to endosomes but transmits sustained signals from plasma membrane rafts.| | PubMed PubMed
- The TGR5 receptor mediates bile acid-induced itch and analgesia.| | PubMed PubMed
- Activation of G protein-coupled bile acid receptor, TGR5, induces smooth muscle relaxation via both Epac- and PKA-mediated inhibition of RhoA/Rho kinase pathway.| | PubMed PubMed
- The receptor TGR5 mediates the prokinetic actions of intestinal bile acids and is required for normal defecation in mice.| | PubMed PubMed
- Localization of calcitonin receptor-like receptor (CLR) and receptor activity-modifying protein 1 (RAMP1) in human gastrointestinal tract.| | PubMed PubMed
- Impairment of central leptin-mediated PI3K signaling manifested as hepatic steatosis independent of hyperphagia and obesity.| | PubMed PubMed
- Visual vignette. What is the diagnosis? Insulin-secreting tumor.| | PubMed PubMed
- Laparoscopic treatment of liver tumours using a two-needle probe bipolar radiofrequency ablation device.| | PubMed PubMed
- Hepatic surgery at a VA tertiary medical center: lessons learned.| | PubMed PubMed
- Periprocedural complications by Child-Pugh class in patients undergoing transcatheter arterial embolization or chemoembolization to treat unresectable hepatocellular carcinoma at a VA medical center.| | PubMed PubMed
- Hydrophobic bile salts inhibit gallbladder smooth muscle function via stimulation of GPBAR1 receptors and activation of KATP channels.| | PubMed PubMed
- Expression and function of the bile acid receptor GpBAR1 (TGR5) in the murine enteric nervous system.| | PubMed PubMed
- Hemorrhagic cholecystitis.| | PubMed PubMed
- Giant mesenteric cystic lymphangioma presenting with abdominal pain and masquerading as a gynecologic malignancy.| | PubMed PubMed
- Reversible surgical model of biliary inflammation and obstructive jaundice in mice.| | PubMed PubMed
- Abdominal actinomycosis after laparoscopic cholecystectomy: a rare complication of bile spillage.| | PubMed PubMed
- Perforated ulcer mimicking a spontaneous pneumothorax in a patient with congenital diaphragmatic hernia.| | PubMed PubMed
- Caudate split for open and laparoscopic liver resections.| | PubMed PubMed
- Basal cell carcinoma does metastasize.| | PubMed PubMed
- Implementation of a multidisciplinary treatment team for hepatocellular cancer at a Veterans Affairs Medical Center improves survival.| | PubMed PubMed
- 18F-fluorodeoxyglucose positron emission tomography influences management decisions in patients with biliary cancer.| | PubMed PubMed
- Agonists of protease-activated receptors 1 and 2 stimulate electrolyte secretion from mouse gallbladder.| | PubMed PubMed
- Role of calcitonin receptor-like receptor in colonic motility and inflammation.| | PubMed PubMed
- Bipolar pulse coagulation for resection of the cirrhotic liver.| | PubMed PubMed
- Recurrent invasive intraductal papillary mucinous carcinoma of the pancreas mimicking pott disease: review of the literature.| | PubMed PubMed
- Clinical and pathologic features of proximal biliary strictures masquerading as hilar cholangiocarcinoma.| | PubMed PubMed
- The missing thyroid.| | PubMed PubMed
- Retrocardiac parathyroid tumor: a rare mediastinal site.| | PubMed PubMed
- Improvement in perioperative outcome after hepatic resection: analysis of 1,803 consecutive cases over the past decade.| | PubMed PubMed
- Role of laparoscopy in the evaluation of biliary tract cancer.| | PubMed PubMed
- Proteinase-activated receptor-2 in human skin: tissue distribution and activation of keratinocytes by mast cell tryptase.| | PubMed PubMed
- Thrombin and mast cell tryptase regulate guinea-pig myenteric neurons through proteinase-activated receptors-1 and -2.| | PubMed PubMed
- The relationship between hospital volume and outcomes of hepatic resection for hepatocellular carcinoma.| | PubMed PubMed
- Desensitization of the neurokinin-1 receptor (NK1-R) in neurons: effects of substance P on the distribution of NK1-R, Galphaq/11, G-protein receptor kinase-2/3, and beta-arrestin-1/2.| | PubMed PubMed
- Proteinase-activated receptors: novel mechanisms of signaling by serine proteases.| | PubMed PubMed
- A hospital's annual rate of esophagectomy influences the operative mortality rate.| | PubMed PubMed
- Mast cell tryptase regulates rat colonic myocytes through proteinase-activated receptor 2.| | PubMed PubMed
- Recent advances. General surgery.| | PubMed PubMed
- Heterogeneity of P2u- and P2y-purinergic receptor regulation of phospholipases in MDCK cells.| | PubMed PubMed
 
    