Biography
Education
Institution | Degree | Dept or School | End Date |
---|---|---|---|
Brigham and Women's Hospital/Harvard Medical School | General Surgery | ||
Brown University | Bachelor of Arts | ||
Memorial Sloan-Kettering Cancer Center | Surgical Oncology Fellowship | ||
National Institutes of Health (NIH)/National Cancer Institute (NCI) | Post-doctorate | Tumor Immunology | |
National Institutes of Health (NIH)/National Cancer Institute (NCI), Surgery Branch | Surgical Oncology Fellowship | ||
Yale University School of Medicine | M.D. |
Board Certifications
American Board of Surgery, General Surgery
Clinical Expertise
Pancreatic Cysts including Intraductal Mucinous Neoplasms of the Pancreas (IPMN) and Mucinous Cystic Neoplasms (MCN)
Colorectal Cancer Liver Metastases
Bile Duct Cancer (Cholangiocarcinoma)
Choledochal Cysts
Gallbladder Cancer
Gastrointestinal Carcinoid Tumor
Gastrointestinal Stromal Tumor (GIST)
Liver Cancer (Hepatocellular Carcinoma)
Liver Cysts
Liver Metastases
Melanoma
Minimally Invasive Robotic and Laparoscopic Liver, Pancreas, & Gastrointestinal Surgery
Pancreatic Cancer
Pancreatic Neuroendocrine Tumors
Soft Tissue Sarcomas
Stomach (Gastric) Cancer
Program Affiliations
Surgical Oncology Clinics, including the Gastrointestinal Oncology Clinic, Liver/pancreas/biliary and soft tissue sarcoma/skin cancer clinics: Mission Bay and Parnassus
Hepatobiliary and Pancreas Surgery Program
UCSF Helen Diller Family Comprehensive Cancer Center
Sarcoma Disease Program
Melanoma/Skin Cancer Disease Program
Grants and Funding
- Stimulating Lymphocyte Activation Combined with Inhibition of Immunosuppressive Signals in Colon Cancer Metastases | NIH | 2020-01-22 - 2024-12-31 | Role: Principal Investigator
- Enhancing anti-tumor immune responses in colon cancer metastases | NIH | 2014-09-17 - 2020-08-31 | Role: Principal Investigator
Research Narrative
Dr. Maker graduated from Brown University with honors in fine arts and biology, completing his honors thesis in the NASA-funded lab of Dr. Herman Vandenberg in tissue engineering. Thereafter, he enrolled in the Yale School of Medicine and was selected to enter the Basic Science Research Training Fellowship where he was awarded the ADA Medical Scholars Award and the AAS/Novartis Research Award for his work in the R01-funded lab of surgeon Dana Andersen on elucidating mechanisms of pancreatogenic diabetes. He completed his general surgery residency at Harvard University’s Brigham and Women’s Hospital and a tumor immunology post-doctorate fellowship in the laboratory of Dr. Steven Rosenberg in the Surgery Branch of the NIH/NCI, during which time he was first author on many of the initial phase I/II trials utilizing anti-CTLA4 antibodies. This work was later honored with the “most cited article” award by the Society of Surgical Oncology.
Dr. Maker went on to complete surgical oncology fellowships at the NCI and Memorial Sloan-Kettering Cancer Center, where he continued translational bench research in the Ludwig Cancer Institute in the labs of Jim Allison and Jed Wolchok, funded, in part, by an ASCO Merit Award and an NCI EDRU U01. He has focused the efforts of his research career on expanding the role of immunotherapy for gastrointestinal tumors and has aligned his clinical practice to coincide with his research interests. His NCI/NIH and DoD-funded research program has identified an immunostimulatory cytokine capable of activating and supporting the proliferation of antigen-specific T-cells to incite an anti-tumor immune response in colorectal liver metastases. This strategy is currently being investigated in combination with oncolytic viruses and immune checkpoint blockade to elicit complete tumor responses. This work has been funded over time as PI by internal funding, the Warren and Clara Cole Foundation of the ACS, the NIH through both K08 and UL1 mechanisms, the DoD (Cancer Impact Award), R37 MERIT from the NCI, and the Society of Surgical Oncology (Investigator of the Year Award).
Dr. Maker's lab also investigates novel drug combinations that stimulate immunogenic cell death and generate anti-tumor immune responses to treat GI tumor liver metastases. As part of these studies, Dr. Maker has developed multiple unique orthotopic animal models in which to study solid organ metastases that has led to multiple federally funded collaborations, including work on the novel Oncopig porcine large animal cancer model for liver and pancreatic cancer.
Furthermore, Dr. Maker has been a leader in the international IPMN biomarkers research group, and has developed a gene signature to predict malignancy in IPMN from pancreatic cyst fluid. He houses the international IPMN cyst fluid repository, one of the largest biobanks of its kind, for which he serves as the international PI. With this collaborative, he is currently validating a single-platform
biosignature to accurately predict the malignant potential of pancreatic cysts.
Finally, as a clinical surgeon with a passion for developing new laparoscopic and robotic techniques in complex surgical oncology, he has also maintained a robust clinical database from which multiple techniques papers and outcomes studies have been generated along with his residents.
Research Interests
Immunotherapies for Cancer
Novel treatments for liver metastases, including colorectal liver metastases
Development of novel immunotherapeutics for metastatic GI cancer, including colorectal liver metastases
Development of biosignatures to guide surgical treatment of pancreatic cancer and pancreatic cysts (IPMN/MCN)
Research Pathways
Publications
- Metastatic melanoma to small bowel: metastasectomy is supported in the era of immunotherapy and checkpoint inhibitors.| | View in PubMed
- Intraoperative hepatic artery infusion pump perfusion testing with indocyanine green near-infrared imaging offers multiple potential advantages.| | View in PubMed
- "Mickey Mouse sign" to identify and remove cystic duct stones in postcholecystectomy syndrome.| | View in PubMed
- Improved survival of patients receiving immunotherapy and chemotherapy following curative-intent resection of colorectal liver metastases.| | View in PubMed
- Educating Cancer-Associated Fibroblasts (CAFs): Are They the Student or the Teacher?| | View in PubMed
- Surgical Cancer Care in Safety-Net Hospitals: a Systematic Review.| | View in PubMed
- Impact of safety-net hospital burden on achievement of textbook oncologic outcomes following resection in for stage I-IV colorectal cancer.| | View in PubMed
- A Machine Learning Approach to Predict Postoperative Pancreatic Fistula After Pancreaticoduodenectomy Using Only Preoperatively Known Data.| | View in PubMed
- ASO Visual Abstract: National Practice Patterns in Malignant Peritoneal Mesothelioma-Updates in Management and Survival.| | View in PubMed
- Non-Canonical Activin A Signaling Stimulates Context-Dependent and Cellular-Specific Outcomes in CRC to Promote Tumor Cell Migration and Immune Tolerance.| | View in PubMed
- National Practice Patterns in Malignant Peritoneal Mesothelioma: Updates in Management and Survival.| | View in PubMed
- It is not necessary to resect all mucinous cystic neoplasms of the pancreas: current guidelines do not reflect the actual risk of malignancy.| | View in PubMed
- Drain Placement After Pancreatic Resection: Friend or Foe For Surgical Site Infections?| | View in PubMed
- Hypertension Requiring Medication Use: a Silent Predictor of Poor Outcomes After Pancreaticoduodenectomy.| | View in PubMed
- The Landmark Series: Intraductal Papillary Mucinous Neoplasms of the Pancreas-From Prevalence to Early Cancer Detection.| | View in PubMed
- Contemporary Trends in Malignant Peritoneal Mesothelioma: Incidence and Survival in the United States.| | View in PubMed
- Hand-Assisted Versus Pure Minimally-Invasive Distal Pancreatectomy: Is There a Downside to Lending a Hand?| | View in PubMed
- Minimally Invasive Distal Pancreatectomy Techniques: A Contemporary Analysis Exploring Trends, Similarities, and Differences to Open Surgery.| | View in PubMed
- The tumour immune microenvironment and microbiome of pancreatic intraductal papillary mucinous neoplasms.| | View in PubMed
- Diagnostic laparoscopy is underutilized in the staging of gastric adenocarcinoma regardless of hospital type: An US safety net collaborative analysis.| | View in PubMed
- Physical exam reveals etiology of liver and pancreatic tumors.| | View in PubMed
- Langer's arch: An anatomic variant complicating axillary node dissection.| | View in PubMed
- Robotic Surgery for Biliary Tract Cancer.| | View in PubMed
- LIGHT enhanced bispecific antibody armed T-cells to treat immunotherapy resistant colon cancer.| | View in PubMed
- Clinical Presentation Patterns and Survival Outcomes of Hispanic Patients With Gastric Cancer.| | View in PubMed
- Attrition during neoadjuvant chemotherapy for gastric adenocarcinoma is associated with decreased survival: A United States Safety-Net Collaborative analysis.| | View in PubMed
- The Evolution of Cancer Immunotherapy.| | View in PubMed
- Is there a difference in utilization of a perioperative treatment approach for gastric cancer between safety net hospitals and tertiary referral centers?| | View in PubMed
- Race and Gender Differences in Awareness of Colorectal Cancer Screening Tests and Guidelines Among Recently Diagnosed Colon Cancer Patients in an Urban Setting.| | View in PubMed
- Combining On-Table Embolization with Immediate Resection to Safely Excise Giant Hepatic Hemangiomas.| | View in PubMed
- Combination Immunotherapy With LIGHT and Interleukin-2 Increases CD8 Central Memory T-Cells In Vivo.| | View in PubMed
- ASO Author Reflections: How Can We Improve the Postoperative Experience for Our Pancreatic Cancer Patients? A Practical Technique to Optimize Pain Control After Major Abdominal Surgery.| | View in PubMed
- Surgeon-Placed Continuous Wound Infusion Pain Catheters Markedly Decrease Narcotic Use and Improve Outcomes After Pancreatic Tumor Resection.| | View in PubMed
- Epidural Analgesia Is Associated with Prolonged Length of Stay After Open HPB Surgery in Over 27,000 Patients.| | View in PubMed
- Perioperative Broad-spectrum Antibiotics are Associated With Decreased Surgical Site Infections Compared to 1st-3rd Generation Cephalosporins After Open Pancreaticoduodenectomy in Patients With Jaundice or a Biliary Stent.| | View in PubMed
- Should Drains Suck? A Propensity Score Analysis of Closed-Suction Versus Closed-Gravity Drainage After Pancreatectomy.| | View in PubMed
- Oncolytic adenovirus encoding LIGHT (TNFSF14) inhibits tumor growth via activating anti-tumor immune responses in 4T1 mouse mammary tumor model in immune competent syngeneic mice.| | View in PubMed
- Management of Cancer Surgery Cases During the COVID-19 Pandemic: Considerations.| | View in PubMed
- A propensity score analysis of over 12,000 pancreaticojejunal anastomoses after pancreaticoduodenectomy: does technique impact the clinically relevant fistula rate?| | View in PubMed
- MADD silencing enhances anti-tumor activity of TRAIL in anaplastic thyroid cancer.| | View in PubMed
- Cyst Fluid Biosignature to Predict Intraductal Papillary Mucinous Neoplasms of the Pancreas with High Malignant Potential.| | View in PubMed
- Loss of MADD expression inhibits cellular growth and metastasis in anaplastic thyroid cancer.| | View in PubMed
- Impact of Immunotherapy after Resection of Pancreatic Cancer.| | View in PubMed
- Molecular aberrations and signaling cascades implicated in the pathogenesis of anaplastic thyroid cancer.| | View in PubMed
- Management of asymptomatic, well-differentiated PNETs: results of the Delphi consensus process of the Americas Hepato-Pancreato-Biliary Association.| | View in PubMed
- Does attending a Delphi consensus conference impact surgeon attitudes? Survey results from the Americas HepatoPancreatoBiliary Association consensus conference on small asymptomatic pancreatic neuroendocrine tumors.| | View in PubMed
- Therapeutic advances in anaplastic thyroid cancer: a current perspective.| | View in PubMed
- ASO Author Reflections: Improving Identification of Intraductal Papillary Mucinous Neoplasm Patients at Risk-Current Status and the Role of IPMN Molecular Biomarkers.| | View in PubMed
- Identification of a Novel OX40L+ Dendritic Cell Subset That Selectively Expands Regulatory T cells.| | View in PubMed
- KRASG12D and TP53R167H Cooperate to Induce Pancreatic Ductal Adenocarcinoma in Sus scrofa Pigs.| | View in PubMed
- Vaccination With Mitoxantrone-Treated Primary Colon Cancer Cells Enhances Tumor-Infiltrating Lymphocytes and Clinical Responses in Colorectal Liver Metastases.| | View in PubMed
- Critical role of OX40 signaling in the TCR-independent phase of human and murine thymic Treg generation.| | View in PubMed
- What is the Incidence of Malignancy in Resected Intraductal Papillary Mucinous Neoplasms? An Analysis of Over 100 US Institutions in a Single Year.| | View in PubMed
- Do Drains Contribute to Pancreatic Fistulae? Analysis of over 5000 Pancreatectomy Patients.| | View in PubMed
- Can we better predict the biologic behavior of incidental IPMN? A comprehensive analysis of molecular diagnostics and biomarkers in intraductal papillary mucinous neoplasms of the pancreas.| | View in PubMed
- Port-Site Resection in the Surgical Management of Incidental Gallbladder Cancer: A Still Inconclusive Question: A Reply.| | View in PubMed
- Examining racial disparities in colon cancer clinical delay in the Colon Cancer Patterns of Care in Chicago study.| | View in PubMed
- The Oncopig Cancer Model: An Innovative Large Animal Translational Oncology Platform.| | View in PubMed
- PKC-ѳ is dispensable for OX40L-induced TCR-independent Treg proliferation but contributes by enabling IL-2 production from effector T-cells.| | View in PubMed
- Perioperative management of endocrine insufficiency after total pancreatectomy for neoplasia.| | View in PubMed
- A Technique to Define Extrahepatic Biliary Anatomy Using Robotic Near-Infrared Fluorescent Cholangiography.| | View in PubMed
- Targeting cancer with tumor-specific therapeutic strategies-metabolic reprogramming beyond the Warburg effect.| | View in PubMed
- Mitochondrial protein 18 (MTP18) plays a pro-apoptotic role in chemotherapy-induced gastric cancer cell apoptosis.| | View in PubMed
- Utilization and impact of adjuvant chemotherapy among patients with resected stage II colon cancer: a multi-institutional analysis.| | View in PubMed
- LIGHT Elevation Enhances Immune Eradication of Colon Cancer Metastases.| | View in PubMed
- Isolated Pancreatic Uncinate Duct IPMN.| | View in PubMed
- Colon cancer cell treatment with rose bengal generates a protective immune response via immunogenic cell death.| | View in PubMed
- Can Colon Cancer Recurrence and Metastases Be Determined After Surgical Resection Using a Gene Expression Signature?| | View in PubMed
- Gene-expression profiling to predict responsiveness to immunotherapy.| | View in PubMed
- Targeting the metabolic pathway of human colon cancer overcomes resistance to TRAIL-induced apoptosis.| | View in PubMed
- Adjuvant chemotherapy is associated with improved survival in patients with stage II colon cancer.| | View in PubMed
- Techniques to perform robotic left adrenalectomy in the obese patient.| | View in PubMed
- Hepatectomy After Yttrium-90 (Y90) Radioembolization-Induced Liver Fibrosis.| | View in PubMed
- A Minimally Invasive Technique to Obtain Optimal Tumor Margins in Anatomically Confined Locations Using a Contoured Stapler.| | View in PubMed
- Precise identification of immunotherapeutic targets for solid malignancies using clues within the tumor microenvironment-Evidence to turn on the LIGHT.| | View in PubMed
- The Potential of Intralesional Rose Bengal to Stimulate T-Cell Mediated Anti-Tumor Responses.| | View in PubMed
- Techniques to perform a laparoscopic right adrenalectomy for metastases abutting the liver, renal vein, and posterior vena cava.| | View in PubMed
- Symptomatic Massive Splenomegaly in Persistent Polyclonal B-cell Lymphocytosis Requiring Splenectomy.| | View in PubMed
- Tailoring GIST therapy—biology is still king.| | View in PubMed
- Essential roles of FoxM1 in Ras-induced liver cancer progression and in cancer cells with stem cell features.| | View in PubMed
- Simultaneous Occurrence of Glandular and Neuroendocrine Components in Lymph Node Metastasis of Gastric MANEC.| | View in PubMed
- Closure of Melanoma Defects on the Sole of the Foot Using Glaborous Skin: The End of the Flap?| | View in PubMed
- Operative management of portal annular pancreas during pancreaticoduodenectomy.| | View in PubMed
- Genetic evidence that intratumoral T-cell proliferation and activation are associated with recurrence and survival in patients with resected colorectal liver metastases.| | View in PubMed
- Cyst fluid biomarkers for intraductal papillary mucinous neoplasms of the pancreas: a critical review from the international expert meeting on pancreatic branch-duct-intraductal papillary mucinous neoplasms.| | View in PubMed
- Appendicitis secondary to metastatic melanoma: review of the National Institutes of Health experience.| | View in PubMed
- Calcifying fibrous tumor of the small intestine associated with Castleman-like lymphadenopathy.| | View in PubMed
- Dedifferentiated gastrointestinal stromal tumor arising de novo from the small intestine.| | View in PubMed
- IG20/MADD plays a critical role in glucose-induced insulin secretion.| | View in PubMed
- Gene expression profiles accurately predict outcome following liver resection in patients with metastatic colorectal cancer.| | View in PubMed
- Benign adrenal hemangiomas may mimic metastases on PET.| | View in PubMed
- Management of patients with abdominal malignancy after remote jejunoileal bypass: surgical considerations decades later.| | View in PubMed
- A technique for laparoendoscopic resection of posterior fundic gastric GISTs without need for a gastrotomy.| | View in PubMed
- Survival after resection of cutaneous adnexal carcinomas with eccrine differentiation: risk factors and trends in outcomes.| | View in PubMed
- Shedding LIGHT (TNFSF14) on the tumor microenvironment of colorectal cancer liver metastases.| | View in PubMed
- MADD knock-down enhances doxorubicin and TRAIL induced apoptosis in breast cancer cells.| | View in PubMed
- Primary hepatic lymphoma presenting as an isolated solitary hepatic cyst.| | View in PubMed
- Can we predict which residents are going to pass/fail the oral boards?| | View in PubMed
- Regulatory T cell infiltration predicts outcome following resection of colorectal cancer liver metastases.| | View in PubMed
- Malignant masquerade of xanthogranulomatous cholecystitis on intraoperative ultrasound of the liver.| | View in PubMed
- Video: totally laparoscopic left lateral segmentectomy for hepatic malignancies: a modified technique.| | View in PubMed
- Is port site resection necessary in the surgical management of gallbladder cancer?| | View in PubMed
- Knockdown of MADD and c-FLIP overcomes resistance to TRAIL-induced apoptosis in ovarian cancer cells.| | View in PubMed
- Cyst fluid interleukin-1beta (IL1beta) levels predict the risk of carcinoma in intraductal papillary mucinous neoplasms of the pancreas.| | View in PubMed
- Pancreatic cyst fluid and serum mucin levels predict dysplasia in intraductal papillary mucinous neoplasms of the pancreas.| | View in PubMed
- Randomized clinical trials in pancreatic adenocarcinoma.| | View in PubMed
- Novel presentation of a familial pancreatic cancer syndrome.| | View in PubMed
- Cytology from pancreatic cysts has marginal utility in surgical decision-making.| | View in PubMed
- Intrapatient dose escalation of anti-CTLA-4 antibody in patients with metastatic melanoma.| | View in PubMed
- Selective elimination of human regulatory T lymphocytes in vitro with the recombinant immunotoxin LMB-2.| | View in PubMed
- Analysis of the cellular mechanism of antitumor responses and autoimmunity in patients treated with CTLA-4 blockade.| | View in PubMed
- Images in cardiothoracic surgery. Active malignant pleural effusion captured through the thoracoscope.| | View in PubMed
- Inability of a fusion protein of IL-2 and diphtheria toxin (Denileukin Diftitox, DAB389IL-2, ONTAK) to eliminate regulatory T lymphocytes in patients with melanoma.| | View in PubMed
- Tumor regression and autoimmunity in patients treated with cytotoxic T lymphocyte-associated antigen 4 blockade and interleukin 2: a phase I/II study.| | View in PubMed
- Loss of S100 antigenicity in metastatic melanoma.| | View in PubMed
- Autoimmunity correlates with tumor regression in patients with metastatic melanoma treated with anti-cytotoxic T-lymphocyte antigen-4.| | View in PubMed
- Rapid acute amiodarone-induced hepatotoxicity in a burn patient.| | View in PubMed
- Insulin receptor (IR) and glucose transporter 2 (GLUT2) proteins form a complex on the rat hepatocyte membrane.| | View in PubMed